Physical and inflammatory aspects associated to respiratory sarcopenia in community-dwelling older women - da Costa Teixeira, Leonardo Augusto; de Carvalho Bastone, Alessandra; Soares, Luana Aparecida; dos Santos Mourão, Maria Fernanda; Nobre, Juliana Nogueira Pontes; Viegas, Ângela Alves; Parentoni, Adriana Netto; Figueiredo, Pedro Henrique Scheidt; Taiar, Redha; Mendonça, Vanessa Amaral; Lacerda, Ana Cristina Rodrigues (Scientific Reports, 2025)
To investigate the relationship between respiratory sarcopenia with physical tests and a set of inflammatory biomarkers, seventy-one older women from the community with age 75 ± 7 years and BMI 26 ± 4 kg/m² were evaluated for appendicular lean mass using Dual X-ray Absorptiometry, respiratory muscle strength using an analog manuvacuometer, physical tests using handgrip strength, timed up and go and sit to stand in chair tests, and a panel of inflammatory biomarkers was measured, containing Adiponectin, BNDF, IFN, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, Leptin, Resistin, TNF and their soluble receptors sTNFr-1 and sTNFr-2. The analyzes suggest that older women with respiratory sarcopenia also had significantly low physical function and higher concentrations of sTNFr-2 (> 2241pg/ml), additionally respiratory muscle strength was inversely associated with sTNFr-2 concentrations (MIP: β = -0.48; R² = 0.24; p < 0.001; MEP: β = -0.35; R² = 0.12; p = 0.003). These results contribute to the discussion about the pathophysiology and to the strategies for diagnosing and monitoring respiratory sarcopenia in community-dwelling older women.
Keywords: journalArticle; Biomarkers; Diagnosis; Geriatrics; Immunology; Interleukins; Tumour-necrosis factors